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HFC Disconnect

See HFC Disconnect Products

The HFC Disconnect Series enables sterile disconnection of single-use biopharma and cell and gene therapy manufacturing systems. With an easy push of the connector thumb latch, sterility is maintained on both sides of the system during the disconnection process. Ideal for disconnection from storage/mixing tanks, SU bioreactors, transfer lines, chromatography skids, filters, sampling, and freeze/thaw bags. Sold in the connected set, including a protective thumb latch cover eliminating the chance of an accidental disconnection. Laser etched with item and lot number for batch traceability.

Assets & Downloads

Intuitive one-step disconnection processMinimize operation error and eases standard operation procedure creation and training
Ease of connectivityNo requirement for additional equipment to make sterile disconnection
Audible "click"Provides confidence of a secure connection
Protective thumb latch coverEliminate accidental disconnects
Laser etched item number and lot numberFull traceability to raw material source
Alloy C-276 internal flow path springEnabling broader application compatibility

Specifications & CV Value

Operating Conditions (Fluid Transfer)

Pressure: Up to 75 psi, 5.17 bar
Temperature: 34°F (1°C) to 104°F (40°C)


Main components: Polysulfone (amber tint), USP Class VI, ADCF
O-rings: Silicone (clear), platinum-cured, USP Class VI, ADCF
Flow Path Springs: Alloy C-276


Gamma: Up to 50 kGy irradiation.Sterilize coupled or uncoupled.
Autoclave: Up to 270°F (132°C) for 60 minutes. One cycle

Cv Value

HFC Disconnect 1/4” CV Value 0.77
HFC Disconnect 3/8” CV Value 1.1
HFC Disconnect 1/2” CV Value 1.9
Cv values are based on gpm and psi, and Ipm and bar (shown in parentheses).
WARNING: Pressure, temperature, chemicals and operating environment can affect the performance of couplings. It is the customer’s responsibility to test the suitability of Colder products in their own application conditions.

Validation Reports

Extractables Reports





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