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    Aseptic Connectors for Cell Culture

    All living things grow by cellular division which is the same for cell culture―cells divide and multiply in a suitable environment. With cells being the basic biological unit of living things, cell culture is essential for biopharmaceutical research and development. Cell culture is used to diagnose infections, test new drugs and for research. With the behavior of living cells being highly complex with thousands of chemical reactions, cells are extremely sensitive to even the smallest changes in their environment.

    Ongoing Advances in Cell Culture

    Biopharmaceutical manufacturers need to develop high-producing cell lines as quickly as possible. Today’s cell culture systems are producing higher titers while decreasing the time from bench to production bioreactor. With enhancements in cell engineering, culture conditions and culture analysis, new techniques and optimized cell environments are being developed to maximize cell growth.


    Fundamental Cell Culture Process

    • Cells are removed from an organism
    • Removed cells are introduced into an artificial environment with the necessary nutrients, ideal temperature, gases, acidity, and humidity
    • Cells are kept alive and grow

    CPC’s Expertise and Experience Aid Cell Culture Workflow Processes

    CPC understands that cell line development involves multiple, complex processes requiring consistency and reproducible results. When manufacturers are creating cell models for drug discovery, drug development, or drug production, CPC aseptic connectors have the right connection technologies to help advance the cell culture manufacturing workflow process.

    Our broad portfolio of innovative aseptic connectors helps maximize productivity, while reducing costs, eliminating contamination risk and helping speed time to market. As a global partner, CPC’s expert team of design engineers and application specialists are on hand to collaborate with biopharma manufacturers to advance cell culture production. 

    Seed Train with CPC Aseptic Connectors

    Cell culture systems connected to a cell culture single-use media storage container use an AseptiQuik® or MicroCNX Aseptic Connector using flexible tubing. Likewise, flexible tubing with CPC aseptic connectors is used for transfer lines between each reactor in the process. For production volumes over 1,000 L, a single-use bioreactor must ultimately seed one or more stainless steel bioreactors. Steam-Thru® Connections incorporated into the single-use bioreactor design can link the single-use and stainless-steel section of a seed train.


    CPC Aseptic Connectors Provide Competitive Advantage

    Robust media transfer connection technology helps mitigate the risk of process contamination. Single-use CPC aseptic connectors support strict cell culture sterility requirements. A range of CPC sterile connectors ensure closed connection and disconnection to transfer media and cells. They are designed to be used with bag and bottle assemblies for growing cells and cell culture scale up. By helping optimize cell line development, CPC aseptic connectors provide a competitive advantage with increased efficiency and reduced contamination risk.

    CPC Aseptic Connectors Seal Design

    CPC's robust seal design is the last line of defense against leakage or microbial ingress into the connector and the system. CPC aseptic connectors well-designed seal ensures:

    • Seal stays in place throughout the actuation steps
    • Connector withstands side loading, flexing, and tensile forces without compromising the integrity of the seal
    • Larger, more robust seals in both halves of the connector

    Versatility and Flexibility

    CPC aseptic connectors provide flexibility for biopharmaceutical manufacturers to easily combine multiple components including process containers, tubing manifolds, single-use and metal transfer lines, bioreactors and other bioprocess equipment. When changeovers need to occur, genderless CPC aseptic connectors make it easy to connect components and processes. Multiple termination options meet today’s mounting and flow requirements.

    Innovative Design

    Our team of bioprocessing design and application engineers develop innovative, high-quality products that make sterile media transfer safe and easy. Because cell culture systems and processes vary, process designers and engineers choose from a continually expanding CPC aseptic connectors and disconnects portfolio with a broad range of sizes, configurations, termination options and materials. Innovative connection methods help eliminate contamination risk and ensure connection assurance.

    Trusted Reliability

    CPC aseptic connectors are purpose-built for bioprocessing applications including upstream cell culture. By helping maintain aseptic transfer of media, CPC sterile connectors facilitate getting the best yields at a cost-effective price. All CPC aseptic connection solutions are rigorously tested ─ including materials testing, product testing and torture testing to failure ─ to meet product specifications. As a matter of fact, CPC offers reliable, reproducible performance and provides validation and extractable reports that support the performance attributes.

    Overall Robustness

    Engineered to help manage the strict cell culture standards requirements, CPC aseptic connectors deliver optimized flowrates with excellent flow to size ratio for superior performance. CPC purpose-built media transfer connectors are designed to be compatible with the wide variety of environments used in cell culture. We provide a unique combination of industry expertise with the broadest portfolio of products including sterile connects, sterile disconnects, SIP connections and quick connects.

    Sterility Assurance

    Increased volume and product diversity is driving manufacturers to design their facilities for shorter production runs with multiple changeovers. Single-use bags and transfer lines use CPC MPC or MPX Connections and SaniQuik Adaptors for quick changeovers. Robust and easy-to-use single-use connectors from CPC maintain flow path sterility and integrity while enabling biopharmaceutical manufacturers to use the necessary cell culture systems to improve productivity, lower contamination risks and reduce costs.

    Assurance of Supply

    CPC has a proven track record of providing products consistently under their stated specifications and quality requirements through having a strong supply assurance program. The program includes control of the manufacturing process from raw materials to final product manufacturing. Biopharma customers have confidence in CPC’s ability to fulfill demand acquired by a track record of accurate lead times, identifying and communicating potential delays and, most importantly, by sound supply chain management.

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