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    Perfusion and Continuous Processing

    Perfusion and continuous processing have emerged as viable technologies for the commercial production of biopharmaceuticals. Perfusion allows the production of sensitive proteins that degrade when left in bioreactors under batch and fed-batch operations. The perfusion method circulates medium through a growing culture, allowing simultaneous removal of waste, supply of nutrients and harvesting of product. Continuous processing creates a product with no need to stop until the product is finished, unlike batch processing which stops from step to step throughout product creation. 

    Biopharma Manufacturing Constantly Evolving to Meet New Market Demands

    Biopharma manufacturers are increasingly focused on smaller-volume, targeted therapies often produced in smaller, more flexible facilities designed to manufacture multiple products. This new focus coupled with advances in perfusion and continuous processing technologies have increased adoption. Perfusion technologies, used in conjunction with single-use systems, help meet market demand changes more rapidly, while reducing capital investment, cleaning and validation costs, as well as equipment footprint. For example, learn how single-use connectors are bridging the gap between traditional sensors.

    Potential Benefits of Continuous Processing

    • Improved time-efficiency
    • Reduced energy needs
    • Increase productivity
    • Reduced amount of overall waste
    • Lowered risk of human error because fewer people participate in production process from start to finish

    Perfusion and Continuous Processing Help Drive Down Operating Costs

    Manufacturing sites using perfusion processes generally require smaller bioreactors (i.e., 2,000 L versus 20,000 L) which reduces facility footprint size, scale-up time and costs. In addition, perfusion allows for the same size bioreactor to be used for multi-product production. To meet the yearly production requirements of multi-products, the perfusion and continuous processes run longer or shorter culture times, operating continuously for 30-100 days (while traditional batch and fed-batch systems run for about 10-14 days).

    Partner with CPC to Help Improve Your Perfusion and Continuous Processing

    Biopharma manufacturers are seeking technologies, like perfusion and continuous processing, that can provide competitive advantage. CPC’s bioprocessing engineering team collaborates with you to accelerate your perfusion and continuous processing workflows. CPC has over 20 years of experience with safe and efficient media transfer using single-use connection technology and aseptic connectors. With a market-neutral position and global distribution, CPC products are available everywhere, all the time.

    Enhance Perfusion Systems and Continuous Processing with CPC Single-Use Aseptic Connectors

    CPC’s broad range of aseptic connectors address the safe media transfer needs of faster product changeovers for small-batch production used in perfusion and continuous processes. Engineered for biopharmaceutical manufacturing, our genderless, sterile connectors simplify process integration, maximize flexibility and streamline your supply chain. Innovative connection technology from CPC helps meet the demands for rapid drug development, sterility assurance and improved manufacturing productivity.


    Advantages of CPC Aseptic Connectors

    • Flexibility to work with any type of tubing
    • Allow any type of tubing to be connected to any other
    • No electricity required
    • Minimal, in any, training needed
    • No maintenance required
    • No particulates generated
    • Faster speed of connection

    Biopharmaceutical manufacturers deploy a wide range of single-use subsystems including bags, single-use transfer lines, tubing manifolds and filter assemblies to create their optimal production processes. CPC offers a wide variety of single-use connector solutions to reliably perform perfusion and continuous processing while maintaining sterility and system integrity.

    Versatility and Flexibility

    CPC sterile connectors provide flexibility for biopharmaceutical manufacturers to easily combine multiple components including process containers, tubing manifolds, single-use and metal transfer lines, bioreactors and other bioprocess equipment. When changeovers need to occur, CPC genderless connectors make it easy to connect components and processes. Multiple termination options meet today’s mounting and flow requirements.

    Innovative Design

    Our team of bioprocessing design and application engineers develop innovative, high-quality products that make sterile media transfer safe and easy. Because perfusion and continuous processing systems vary as much as the options for tubing, connectors and filters, CPC aseptic connectors and disconnects come in an expanding variety of sizes, configurations, termination options and materials. Innovative connection methods ensure ease of use and connection assurance.

    Trusted Reliability

    CPC sterile connectors are purpose-built for bioprocessing applications like upstream perfusion and continuous processing. By helping maintain aseptic transfer of media, CPC sterile connectors facilitate getting the best yields at a cost-effective price. All CPC aseptic connection solutions are rigorously tested including materials testing, product testing and torture testing to failure to meet product specifications. As a matter of fact, CPC offers reliable, reproducible performance and provides validation and extractable reports that support the performance attributes.

    Overall Robustness

    Built to manage the continuous processing transfer requirements of cell culture production, CPC sterile connectors deliver optimized flowrates with excellent flow to size ratio for superior performance. CPC purpose-built bioprocessing connectors are precision engineered to be compatible with a wide variety of media, chemicals and systems. We provide a unique combination of industry expertise with the broadest portfolio of products including sterile connects, sterile disconnects, SIP connections and quick connects.

    Sterility Assurance

    Increased volume and product diversity is driving manufacturers to design their facilities for shorter production runs with multiple changeovers. Single-use bags and transfer lines use CPC MPC or MPX Connections and SaniQuik™ Adaptors for quick changeovers. Robust and easy-to-use single-use connectors from CPC maintain flow path sterility and integrity while enabling biopharmaceutical manufacturers to use perfusion and continuous processing systems to improve productivity, decrease time-to-market and reduce costs.

    Assurance of Supply

    CPC has a proven track record of providing products consistently under their stated specifications and quality requirements through having a strong supply assurance program. The program includes control of the manufacturing process from raw materials to final product manufacturing. Biopharma customers have confidence in CPC’s ability to fulfill demand acquired by a track record of accurate lead times, identifying and communicating potential delays and, most importantly, by sound supply chain management.

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