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Q&A: Connectors for Hybrid Single-Use/Reusable Systems

What is a hybrid system?

A hybrid system in biopharmaceutical manufacturing is one that utilizes both fixed, reusable equipment (such as stainless steel bioreactors) and flexible, single-use equipment. In essence, a hybrid system is a halfway point between fully reusable and fully single-use.

Why use a hybrid system instead of a fully disposable or fully reusable solution?

The classic approach for biopharmaceutical processing facilities has been to utilize only reusable stainless steel equipment—including bioreactors, piping, valves and storage vessels. As single use technologies advanced and their adoption accelerated, more manufacturers have elected to add single-use systems as a strategy to reduce costs, cross-contamination and downtime.

How is a single-use system connected to fixed equipment?

Many suppliers deliver single-use components that are pre-sterilized and ready to use. However, these pre-sterilized single-use systems still need to be connected to the fixed equipment in an aseptic manner. One of the most common ways to do this is with single use steam-in-place (SIP) connectors, such as Steam-Thru® Connections from CPC.

What is unique about CPC’s Steam-Thru Connections?

The Steam-Thru was recognized by the BioProcess International awards in 2012 as the “Technology of the Decade” because of its role in the industry’s transition to utilizing more single-use systems. Steam-Thru Connections allow a quick and easy sterile connection between stainless steel bioprocessing equipment and disposable bag and tube assembles.

Looking for more? Read the entire Q&A here.

Additional Resources

Products: AseptiQuik/Sterile

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